Well, I am now at the 6 month mark. Things have been great. I have not had one trace of sweat in my palms. I generally meet with different people throughout the day, and I have not found myself wiping my hands on my pants prior to shaking anyone's hand. I guess the indication of having Botox for Hyperhidrosis is around 2 to 6 months, but I have not noticed a regression back to sweaty palms.